منابع مشابه
Review: flumazenil leads to clinical and electroencephalographic improvement in hepatic encephalopathy in patients with cirrhosis.
M a i n r e s u l t s 6 placebo-controlled studies involving 641 patients (326 assigned to flumazenil and 315 assigned to placebo) met the selection criteria. Treatment duration ranged from 5 minutes to 3 days. Combining data from 5 trials (317 patients assigned to flumazenil and 306 to placebo) showed that more patients who received flumazenil had clinical improvement than did those who receiv...
متن کاملFlumazenil vs. placebo in hepatic encephalopathy in patients with cirrhosis: a meta-analysis.
BACKGROUND Randomized controlled trials testing flumazenil in hepatic encephalopathy have shown conflicting results. AIM To compare flumazenil and placebo in hepatic encephalopathy in patients with cirrhosis. METHODS An overview of randomized controlled trials comparing flumazenil and placebo in hepatic encephalopathy in patients with cirrhosis was performed. For each end-point, heterogenei...
متن کاملHepatic encephalopathy
Hepatic encephalopathy (HE) is a reversible syndrome of impaired brain function occurring in patients with advanced liver diseases. The precise pathophysiology of HE is still under discussion; the leading hypothesis focus on the role of neurotoxins, impaired neurotransmission due to metabolic changes in liver failure, changes in brain energy metabolism, systemic inflammatory response and altera...
متن کاملHepatic Encephalopathy
The liver is the most important organ for the well-functioning of other organs because of its vital role in nutrition, metabolism and secretion. Any disturbance in normal homeostasis of liver as it happens in acute liver failure (ALF) and chronic liver disease (cirrhosis) will lead to extra hepatic manifestations of liver disease, among them one is encephalopathy. And this encephalopathy caused...
متن کاملHepatic Encephalopathy
Hepatic encephalopathy (HE) is a brain disorder caused by chronic liver failure, particularly in alcoholics with cirrhosis, which results in cognitive, psychiatric, and motor impairments. In these patients, the number of functional liver cells is reduced, and some blood is diverted around the liver before toxins are removed. As a result, toxins such as ammonia and manganese can accumulate in th...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1999
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.510290433